Polypharmacy treatments can lead to serious adverse effects due to adverse drug events (ADEs), drug-drug interactions (DDIs), drug-condition interactions (DCIs), and drug-gene interactions (DGIs). Clinical decision support (CDS) systems alert doctors to potential adverse drug reactions (ADRs) but do not provide alternative treatment options.
​
​The article Preventable Adverse Drug Reactions: A Focus on Drug Interactions by the US Food & Drug Administration Agency highlights alarming findings, suggesting that ADRs could be the fourth leading cause of death in the United States. The report concludes that ADRs pose a major public health challenge, most of which are preventable.
 
Specialized clinical decision support tool PM-TOM (Personalized Medicine—Therapy Optimization Method), aid in identifying alternative polypharmacy treatments with reduced adverse drug reactions and interactions. Interactive examples on this site demonstrate how PM-TOM can optimize polypharmacy treatments for common diseases and support the deprescribing process.